Tnf^tm1.2Sned
Targeted Allele Detail

Summary

• Symbol: Tnf^tm1.2Sned
• Name: tumor necrosis factor; targeted mutation 1.2, Sergei A Nedoskasov
• MGI ID: MGI:3576929
• Synonyms: TNF^delta
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Tnf^tm1.2Sned page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 and 4 were deleted via cre-mediated recombination following the insertion of loxP sites and a floxed neo into intron 2 and the 3' UTR, respectively. (J:97783)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 48 strains or lines available

References

• Original: J:97783 Kuprash DV, et al., Novel tumor necrosis factor-knockout mice that lack Peyer's patches. Eur J Immunol. 2005 May;35(5):1592-600
• All: 7 reference(s)