Ybx2^tm1Nbh
Targeted Allele Detail

Summary

• Symbol: Ybx2^tm1Nbh
• Name: Y box protein 2; targeted mutation 1, Norman B Hecht
• MGI ID: MGI:3576937
• Synonyms: Msy2^-, Msy2^tm1Nbh
• Gene: Ybx2 Location: Chr11:69826652-69832430 bp, + strand Genetic Position: Chr11, 42.93 cM, cytoband B4
• Alliance: Ybx2^tm1Nbh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97817
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3, which encode amino acids essential for the nucleic-acid-binding cold-shock domain were replaced with a PGK-HPRT cassette. Northern and Western blot analyses confirmed absence of transcript and protein in mutant testes, respectively. (J:97817)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ybx2 Mutation: 20 strains or lines available

References

• Original: J:97817 Yang J, et al., Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility. Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5755-60
• All: 7 reference(s)