Pcsk9^tm1Jdh
Targeted Allele Detail

Summary

• Symbol: Pcsk9^tm1Jdh
• Name: proprotein convertase subtilisin/kexin type 9; targeted mutation 1, Jay D Horton
• MGI ID: MGI:3577021
• Synonyms: Pcsk9^-
• Gene: Pcsk9 Location: Chr4:106299531-106321522 bp, - strand Genetic Position: Chr4, 49.67 cM
• Alliance: Pcsk9^tm1Jdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97836
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a neomycin resistance gene was inserted to replace the 3' half of exon 2 through exon 4. Northern blot of mutant livers confirmed absence of transcript. Immunoblot of livers further confirmed absence of protein. (J:97836)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcsk9 Mutation: 46 strains or lines available

References

• Original: J:97836 Rashid S, et al., Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5374-9
• All: 35 reference(s)