Ppif^tm1Tsu
Targeted Allele Detail

Summary

• Symbol: Ppif^tm1Tsu
• Name: peptidylprolyl isomerase F (cyclophilin F); targeted mutation 1, Yoshihide Tsujimoto
• MGI ID: MGI:3577023
• Gene: Ppif Location: Chr14:25694578-25700892 bp, + strand Genetic Position: Chr14, 15.06 cM
• Alliance: Ppif^tm1Tsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97673
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ/MCI-neo cassette replaced exons 1-5. Western blot of lysates from various tissues confirmed absence of protein. (J:97673)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppif Mutation: 20 strains or lines available

References

• Original: J:97673 Nakagawa T, et al., Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature. 2005 Mar 31;434(7033):652-8
• All: 7 reference(s)