Rbbp8^tm1Whl
Targeted Allele Detail

Summary

• Symbol: Rbbp8^tm1Whl
• Name: retinoblastoma binding protein 8, endonuclease; targeted mutation 1, Wen-Hwa Lee
• MGI ID: MGI:3577029
• Synonyms: Ctip^-
• Gene: Rbbp8 Location: Chr18:11766333-11876264 bp, + strand Genetic Position: Chr18, 5.85 cM
• Alliance: Rbbp8^tm1Whl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97648
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-NeopA was inserted into exon 5 at the position equivalent to amino acid residue 109 in the human protein. (J:97648)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rbbp8^tm1Whl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbbp8 Mutation: 51 strains or lines available

References

• Original: J:97648 Chen PL, et al., Inactivation of CtIP Leads to Early Embryonic Lethality Mediated by G1 Restraint and to Tumorigenesis by Haploid Insufficiency. Mol Cell Biol. 2005 May;25(9):3535-42
• All: 5 reference(s)