Tgif1^tm1.1Caw
Targeted Allele Detail

Summary

• Symbol: Tgif1^tm1.1Caw
• Name: TGFB-induced factor homeobox 1; targeted mutation 1.1, Christopher A Walsh
• MGI ID: MGI:3577049
• Synonyms: Tgif^-
• Gene: Tgif1 Location: Chr17:71151200-71160527 bp, - strand Genetic Position: Chr17, 41.87 cM
• Alliance: Tgif1^tm1.1Caw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97642
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Tgif^tm1Caw mice were crossed with mice expressing cre in the germline to produce this allele in which exons 2 and 3 are deleted. Western blot demonstrated lack of protein in mutant embryos. (J:97642)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgif1 Mutation: 52 strains or lines available

References

• Original: J:97642 Shen J, et al., Targeted disruption of tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice. Mol Cell Biol. 2005 May;25(9):3639-47
• All: 5 reference(s)