Rhpn2^tm1Ssch
Targeted Allele Detail

Summary

• Symbol: Rhpn2^tm1Ssch
• Name: rhophilin, Rho GTPase binding protein 2; targeted mutation 1, Stephanie Schurmans
• MGI ID: MGI:3577068
• Synonyms: Rhpn2^-
• Gene: Rhpn2 Location: Chr7:35033605-35091712 bp, + strand Genetic Position: Chr7, 21.36 cM
• Alliance: Rhpn2^tm1Ssch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97638
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The last 28 nucleotides of exon 7 and about 1 kb of intron 7 were replaced by a neomycin resistance gene. Northern and Western blot of mutants confirmed absence of transcript and protein in brain and kidney samples. (J:97638)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhpn2 Mutation: 40 strains or lines available

References

• Original: J:97638 Behrends J, et al., Normal thyroid structure and function in rhophilin 2-deficient mice. Mol Cell Biol. 2005 Apr;25(7):2846-52
• All: 2 reference(s)