Safb^tm1So
Targeted Allele Detail

Summary

• Symbol: Safb^tm1So
• Name: scaffold attachment factor B; targeted mutation 1, Steffi Oesterreich
• MGI ID: MGI:3577076
• Synonyms: SAFB1^-
• Gene: Safb Location: Chr17:56891982-56913294 bp, + strand Genetic Position: Chr17, 29.4 cM
• Alliance: Safb^tm1So page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97633
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 7-13 were repd with a IRES-LacZ-neo cassette. These exons encoded the ERalpha interaction domain and RD. RT-PCR analysis demonstrated absence of the C-terminal transcript in mutant brain and testis. Immunoblot confirms the absence of full-length protein, as well as a smaller truncated protein, in mutant brain and embryo samples. (J:97633)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Safb Mutation: 43 strains or lines available

References

• Original: J:97633 Ivanova M, et al., Scaffold attachment factor B1 functions in development, growth, and reproduction. Mol Cell Biol. 2005 Apr;25(8):2995-3006
• All: 1 reference(s)