Ppif^tm1Jmol
Targeted Allele Detail

Summary

• Symbol: Ppif^tm1Jmol
• Name: peptidylprolyl isomerase F (cyclophilin F); targeted mutation 1, Jeffery D Molkentin
• MGI ID: MGI:3577093
• Synonyms: Ppif^-
• Gene: Ppif Location: Chr14:25694578-25700892 bp, + strand Genetic Position: Chr14, 15.06 cM
• Alliance: Ppif^tm1Jmol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97660
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the first three coding exons. Western blot of cardiac protein extracts from mutants demonstrated the lack of protein. (J:97660)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppif Mutation: 20 strains or lines available

References

• Original: J:97660 Baines CP, et al., Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature. 2005 Mar 31;434(7033):658-62
• All: 71 reference(s)