Recql5^tm1.1Glu
Targeted Allele Detail

Summary

• Symbol: Recql5^tm1.1Glu
• Name: RecQ protein-like 5; targeted mutation 1.1, Guangbin Luo
• MGI ID: MGI:3577100
• Synonyms: M3
• Gene: Recql5 Location: Chr11:115783421-115824303 bp, - strand Genetic Position: Chr11, 80.91 cM, cytoband E2
• Alliance: Recql5^tm1.1Glu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97667
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: To disrupt the production of any isoform, Recql5^tm1Glu mice were crossed with mice expressing cre in the germline to removed exon 4, causing a frameshift at codon 260. This allele is expected to encode a truncated polypeptide of 260 amino acids, and therefore either an N-terminal truncated protein without any discernable domain or no protein at all. (J:97667)

Tumor Data

List all tumor models in MMHCdb carrying Recql5^tm1.1Glu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Recql5 Mutation: 53 strains or lines available

References

• Original: J:97667 Hu Y, et al., Recql5 and Blm RecQ DNA Helicases Have Nonredundant Roles in Suppressing Crossovers. Mol Cell Biol. 2005 May;25(9):3431-42
• All: 2 reference(s)