H2-D1^bm14
Spontaneous Allele Detail

Summary

• Symbol: H2-D1^bm14
• Name: histocompatibility 2, D region locus 1; b haplotype mutation 14
• MGI ID: MGI:3577203
• Synonyms: H-2^bo, H2^bo, HZW42
• Gene: H2-D1 Location: Chr17:35482070-35486473 bp, + strand Genetic Position: Chr17, 18.61 cM
• Alliance: H2-D1^bm14 page

Mutation origin

• Strain of Origin: C57BL/6By

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: This mutation on the H2^b haplotype is the result of a glutamine to histidine change at amino acid residue 70. Mice display a reduced expression of the H-2.2 specificity. (J:97717, J:98122, J:106337)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2-D1 Mutation: 47 strains or lines available

Notes

Mutation arose in C57BL/6By congenic line Hw42.

References

• Original: J:98122 Morgan GM, et al., Studies of two H-2Db mutants: B6. C-H-2bm13 and B6.C-H-2bm14. Immunogenetics. 1980;11(4):341-9
• All: 16 reference(s)