Summary |
|
||||||||||
Variant origin |
|
||||||||||
Variant description |
|
||||||||||
Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:7521347 female animals from a T Stock x (C3H/HeJ x 102/El)F1 population were treated with 227thorium at 100 days of age to induce osteosarcoma. 54 microsatellite markers were screened in these animals to identify QTLs associated with osteosarcoma susceptibility. Suggestive linkage was detected at 26 cM on mouse Chromosome 7 (LOD=1.37 at D7Mit145) and at 45 cM on mouse Chromsome 14 (LOD=105 at D14Mit219.) When both loci were analyzed together as interacting QTL the LOD score increased to 3.48. The chromosome 7 QTL is designated Ossc1 (osteosarcoma susceptibility 1) and the chromosome 14 QTL is designated Ossc2 (osteosarcoma susceptibility 2). The 102/El-derived allele confers resistance to osteosarcomas at Ossc1 but confers susceptibility at Ossc2. 75% of 227thorium-treated animals with susceptibility alleles at both Ossc1 (C3H/HeJ-derived) and Ossc2 (102/El-derived) develop osteosarcoma. Potential candidate genes for Ossc1 are Bax (23 cM), Xrcc1 (5.5 cM), and Fosb (5 cM). A potential candidate gene for Ossc2 is Rb1 (41 cM). |
||||||||||
References |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/21/2024 MGI 6.24 |
![]() |
|