Mbl2^tm1Kata
Targeted Allele Detail

Summary

• Symbol: Mbl2^tm1Kata
• Name: mannose-binding lectin (protein C) 2; targeted mutation 1, Kazue Takahashi
• MGI ID: MGI:3577339
• Synonyms: MBL-C KO
• Gene: Mbl2 Location: Chr19:30210342-30217087 bp, + strand Genetic Position: Chr19, 25.14 cM
• Alliance: Mbl2^tm1Kata page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98124
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by the insertion of a neomycin resistance gene into exon 6. RT-PCR analysis demonstrated the lack of transcript in mutant liver. (J:98124)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mbl2 Mutation: 18 strains or lines available

References

• Original: J:98124 Shi L, et al., Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med. 2004 May 17;199(10):1379-90
• All: 59 reference(s)