Tg(Myh6-Ppif)26.2Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6-Ppif)26.2Jmol
• Name: transgene insertion 26.2, Jeffery D Molkentin
• MGI ID: MGI:3577401
• Synonyms: alphaMHC-CypD-Tg
• Transgene: Tg(Myh6-Ppif)26.2Jmol Location: unknown
• Alliance: Tg(Myh6-Ppif)26.2Jmol page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Ppif)26.2Jmol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppif (MGI:2145814)

• Mutation details: The cDNA was subcloned into a murine alpha-myosin heavy chain promoter expression vector which is expressed in heart tissue. Two transgenic lines are reported. Line 26.2 was the lowest expressing line produced and line 25.4 was the highest expressing line. No distinction was made between the two lines with respect to phenotype. (J:97660)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:97660 Baines CP, et al., Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature. 2005 Mar 31;434(7033):658-62
• All: 4 reference(s)