Lims1^tm1.2Chen
Targeted Allele Detail

Summary

• Symbol: Lims1^tm1.2Chen
• Name: LIM and senescent cell antigen-like domains 1; targeted mutation 1.2, Ju Chen
• MGI ID: MGI:3577473
• Synonyms: PINCH1^-
• Gene: Lims1 Location: Chr10:58159288-58260513 bp, + strand Genetic Position: Chr10, 29.31 cM
• Alliance: Lims1^tm1.2Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97635
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted to flank exon 3 and a neo cassette was inserted into intron 3 flanked by FRT sites. Exon 3 was removed by crossing to mice expressing Cre in the germline, leaving the neo cassette. (J:97635)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lims1 Mutation: 53 strains or lines available

References

• Original: J:97635 Liang X, et al., PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol. 2005 Apr;25(8):3056-62
• All: 1 reference(s)