Pip5k1b^tm1Tssk
Targeted Allele Detail

Summary

• Symbol: Pip5k1b^tm1Tssk
• Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta; targeted mutation 1, Takehiko Sasaki
• MGI ID: MGI:3577649
• Synonyms: PIPKIalpha^-
• Gene: Pip5k1b Location: Chr19:24272158-24533236 bp, - strand Genetic Position: Chr19, 19.44 cM, cytoband C1
• Alliance: Pip5k1b^tm1Tssk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97991
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo replaced a 1.7 kb sequence including exon 3, the region encoding amino acids 68-106. Western blot of BMMCs confirmed absence of protein from the targeted region. (J:97991)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pip5k1b Mutation: 44 strains or lines available

References

• Original: J:97991 Sasaki J, et al., Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med. 2005 Mar 21;201(6):859-70
• All: 7 reference(s)