Nfkbia^tm1.1Kbp
Targeted Allele Detail

Summary

• Symbol: Nfkbia^tm1.1Kbp
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; targeted mutation 1, Klaus Pfeffer
• MGI ID: MGI:3577710
• Synonyms: ikba^delta
• Gene: Nfkbia Location: Chr12:55536195-55539432 bp, - strand Genetic Position: Chr12, 24.0 cM, cytoband C1-C3
• Alliance: Nfkbia^tm1.1Kbp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97945
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Nfkbia^tm1Kbp mice were crossed with cre-expressing mice to remove the promoter region and first two exons in the germ line. All transcripts were lost in tissues analyzed by RT-PCR. (J:97945)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkbia Mutation: 19 strains or lines available

References

• Original: J:97945 Rupec RA, et al., Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity. 2005 Apr;22(4):479-91
• All: 1 reference(s)