Ppp1r17^tm1Nkz
Targeted Allele Detail

Summary

• Symbol: Ppp1r17^tm1Nkz
• Name: protein phosphatase 1, regulatory subunit 17; targeted mutation 1, Toru Nakazawa
• MGI ID: MGI:3577713
• Gene: Ppp1r17 Location: Chr6:55994482-56009674 bp, + strand Genetic Position: Chr6, 27.65 cM, cytoband C1
• Alliance: Ppp1r17^tm1Nkz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97966
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A tau-AFAP-pgk-neo cassette replaced exon 2, which includes the sequence encodinge the initiating methionine. The PGK-neo was subsequently removed via cre-mediated recombination. Northern blot and RT-PCR confirmed lack of transcript in mutant mice. Immunoreactivity was found to be absent in analysis of retinae of mutant mice. (J:97966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppp1r17 Mutation: 16 strains or lines available

References

• Original: J:97966 Nakazawa T, et al., Retinal G-substrate, potential downstream component of NO/cGMP/PKG pathway, is located in subtype of retinal ganglion cells and amacrine cells with protein phosphatases. Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):58-68
• All: 2 reference(s)