Plcg2^Ali5
Chemically induced Allele Detail

Summary

• Symbol: Plcg2^Ali5
• Name: phospholipase C, gamma 2; Abnormal limb 5
• MGI ID: MGI:3577720
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^Ali5 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Sequencing revealed an A to G transition in exon 27, which would result in a aspartic acid to glycine substitution at position 993. (J:97930)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 74 strains or lines available

References

• Original: J:97930 Yu P, et al., Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity. 2005 Apr;22(4):451-65
• All: 6 reference(s)