Abca1^tm1.1Jp
Targeted Allele Detail

Summary

• Symbol: Abca1^tm1.1Jp
• Name: ATP-binding cassette, sub-family A member 1; targeted mutation 1.1, John S Parks
• MGI ID: MGI:3577725
• Synonyms: Abca1^-
• Gene: Abca1 Location: Chr4:53030787-53159895 bp, - strand Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
• Alliance: Abca1^tm1.1Jp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98093
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Abca1^tm1Jp mice were crossed with Tg(EIIa-cre)C5379Lmgd mice to remove exons 45 and 46. (J:98093)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abca1 Mutation: 90 strains or lines available

References

• Original: J:98093 Timmins JM, et al., Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest. 2005 May 2;115(5):1333-1342
• All: 6 reference(s)