Stat5b^tm2Jni
Targeted Allele Detail

Summary

• Symbol: Stat5b^tm2Jni
• Name: signal transducer and activator of transcription 5B; targeted mutation 2, James N Ihle
• MGI ID: MGI:3577898
• Synonyms: Stat5ab^-, Stat5A/B^-, Stat5ab^deltaN, Stat5^deltaN
• Gene: Stat5b Location: Chr11:100671557-100741407 bp, - strand Genetic Position: Chr11, 63.63 cM
• Alliance: Stat5b^tm2Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77412
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon was replaced by a neomycin resistance cassette via homologous recombination in an ES cell line in which the first two coding exons of Stat5a had already been replaced with a hygromycin resistance cassette. This ES cell line was previously used to produce the Stat5a^tm1Jni mouse. The Stat5b targeting vector is the same one used to produce the Stat5b^tm1Jni allele. N-terminally truncated proteins are found at significant levels in the lymphoid lineage by Western Blot analysis (J: 122463). (J:77412, J:122463)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat5b Mutation: 33 strains or lines available

Notes

ES cell line = E14 (129P2/OlaHsd) or RW4 (129X1/SvJ).

References

• Original: J:77412 Teglund S, et al., Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998 May 29;93(5):841-50
• All: 31 reference(s)