Adamts4^tm1.1Eam
Targeted Allele Detail

Summary

• Symbol: Adamts4^tm1.1Eam
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 4; targeted mutation 1.1, Elisabeth A Morris
• MGI ID: MGI:3578001
• Gene: Adamts4 Location: Chr1:171077990-171088206 bp, + strand Genetic Position: Chr1, 79.28 cM
• Alliance: Adamts4^tm1.1Eam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98327
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed exon 4 was excised from Adamts4^tm1Eam via cre-mediated recombination in the germline. RT-PCR confirmed the absence of exon 4 in mutant lung transcripts. (J:98327)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts4 Mutation: 49 strains or lines available

References

• Original: J:98327 Glasson SS, et al., Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum. 2004 Aug;50(8):2547-58
• All: 2 reference(s)