Spi1^tm1.2Nutt
Targeted Allele Detail

Summary

• Symbol: Spi1^tm1.2Nutt
• Name: Spi-1 proto-oncogene; targeted mutation 1.2, Stephen L Nutt
• MGI ID: MGI:3578011
• Synonyms: PU.1^fl
• Gene: Spi1 Location: Chr2:90912750-90946104 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E3
• Alliance: Spi1^tm1.2Nutt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98188
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 5 remained flanked by loxP sites upon the Flp recombinase mediated removal of the IRES-gfp-neo cassette from Sfpi1^tm1Nutt mice. (J:98188)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spi1 Mutation: 28 strains or lines available

References

• Original: J:98188 Dakic A, et al., PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med. 2005 May 2;201(9):1487-502
• All: 23 reference(s)