Dicer1^tm1Mmk
Targeted Allele Detail

Summary

• Symbol: Dicer1^tm1Mmk
• Name: dicer 1, ribonuclease type III; targeted mutation 1, Matthias Merkenschlager
• MGI ID: MGI:3578093
• Synonyms: Dicer^flox, dicer^lox
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^tm1Mmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98192
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 20 and 21, which contain the RNaseII domain, were flanked with loxP sites. A neo with a 5' loxP site was included in the targeting vector and was inserted into intron 19. (J:98192)

Expression

In Mice Carrying this Mutation:	104057 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: myelodysplastic syndrome (Dicer1^tm1Mmk/Dicer1^tm1Mmk Tg(Sp7-tTA,tetO-EGFP/cre)1Amc; J:158901)

References

• Original: J:98192 Cobb BS, et al., T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med. 2005 May 2;201(9):1367-73
• All: 49 reference(s)