Pten^m1un
Chemically induced Allele Detail

Summary

• Symbol: Pten^m1un
• Name: phosphatase and tensin homolog; m1un
• MGI ID: MGI:3578141
• Synonyms: M1un
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^m1un page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: ENU treatment induced a T-to-A mutation changing methionine codon 134 to lysine (p.M134K). The affected residue, adjacent to the phosphatase domain, is evolutonarily conserved. The allele is thought to be hypomorphic. (J:98216)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:98216 Garcia-Garcia MJ, et al., Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5913-9
• All: 2 reference(s)