Arl13b^hnn
Chemically induced Allele Detail

Summary

• Symbol: Arl13b^hnn
• Name: ADP-ribosylation factor-like 13B; hennin
• MGI ID: MGI:3578151
• Gene: Arl13b Location: Chr16:62614048-62667403 bp, - strand Genetic Position: Chr16, 36.43 cM, cytoband C1.2
• Alliance: Arl13b^hnn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered in a screen of G3 progeny of N-ethyl, N-nitrosourea-treated male mice for morphological defects at embryonic day (e) 9.5. It has been identified as a T-o-G transversion (GRCm39:chr16:62651104A>C) in the splice donor sequence of exon 2 which has been shown by RT-PCR to result in exclusion of this exon from mature transcripts and thus of most of a putative GTPase domain, including four consensus nucleotide binding sites, from the encoded protein. Immunoblot analysis reveals the absence of either normally-present protein isoform in mutant embryos. (J:120712)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	88 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arl13b Mutation: 24 strains or lines available

References

• Original: J:98216 Garcia-Garcia MJ, et al., Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5913-9
• All: 16 reference(s)