Rock1^tm1Sna
Targeted Allele Detail

Summary

• Symbol: Rock1^tm1Sna
• Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, Shuh Narumiya
• MGI ID: MGI:3578223
• Synonyms: rock^-, ROCK-I^-
• Gene: Rock1 Location: Chr18:10064401-10182045 bp, - strand Genetic Position: Chr18, 4.91 cM, cytoband A2
• Alliance: Rock1^tm1Sna page

Eyes open at birth and omphalocele phenotypes of Rock1^tm1Sna/Rock1^tm1Sna mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98250
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Beta-galactosidase and neomycin resistance genes replaced exons 3 and 4, which encode part of the kinase domain. Absence of protein was confirmed by immunoblot of whole-brain lysates of mutants. (J:98250)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rock1 Mutation: 60 strains or lines available

References

• Original: J:98250 Shimizu Y, et al., ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol. 2005 Mar 14;168(6):941-53
• All: 4 reference(s)