Gsk3a^tm1Dral
Targeted Allele Detail

Summary

• Symbol: Gsk3a^tm1Dral
• Name: glycogen synthase kinase 3 alpha; targeted mutation 1, Dario R Alessi
• MGI ID: MGI:3578225
• Synonyms: GSK3alpha^21A
• Gene: Gsk3a Location: Chr7:24927683-24937276 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Gsk3a^tm1Dral page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98263
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to replace serine 21, located on exon 1, with alanine (S21A). A floxed neomycin resistance cassette was inserted at the 3' end of exon 1. The neomycin cassette was subsequently excised from properly targeted ES cells by transient transfection with a cre expressing plasmid. (J:98263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gsk3a Mutation: 18 strains or lines available

References

• Original: J:98263 McManus EJ, et al., Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J. 2005 Apr 20;24(8):1571-83
• All: 43 reference(s)