Sod2^tm1.1Kskk
Targeted Allele Detail

Summary

• Symbol: Sod2^tm1.1Kskk
• Name: superoxide dismutase 2, mitochondrial; targeted mutation 1.1, Karin Scharffetter-Kochanek
• MGI ID: MGI:3578627
• Synonyms: Sod2^-
• Gene: Sod2 Location: Chr17:13226726-13237006 bp, + strand Genetic Position: Chr17, 8.75 cM
• Alliance: Sod2^tm1.1Kskk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98289
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3, which encodes 39 amino acids responsible for homodimerization, tetramer formation and manganese binding, was removed via cre-mediated recombination. (J:98289)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Sod2^tm1.1Kskk/Sod2^tm1.1Kskk	involves: 129P2/OlaHsd * C57BL/6
ht2	Sod2^tm1.1Kskk/Sod2^+	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms
behavior/neurological	√
fatigue	√
cardiovascular system	√	√
abnormal myocardial fiber morphology	√	√
cellular	√	√
increased cardiomyocyte apoptosis		√
oxidative stress	√	√
growth/size/body	√
postnatal growth retardation	√
mortality/aging	√
postnatal lethality, complete penetrance	√
muscle	√	√
abnormal myocardial fiber morphology	√	√
increased cardiomyocyte apoptosis		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sod2 Mutation: 26 strains or lines available

References

• Original: J:98289 Strassburger M, et al., Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic Biol Med. 2005 Jun 1;38(11):1458-70
• All: 4 reference(s)