Spry2^tm1Mrt
Targeted Allele Detail

Summary

• Symbol: Spry2^tm1Mrt
• Name: sprouty RTK signaling antagonist 2; targeted mutation 1, Gail R Martin
• MGI ID: MGI:3578632
• Synonyms: Spry2^fl, Spry2^flox
• Gene: Spry2 Location: Chr14:106129381-106134253 bp, - strand Genetic Position: Chr14, 56.16 cM
• Alliance: Spry2^tm1Mrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98303
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo was inserted immediately upstream of the ORF and loxP sites were inserted to flank the ORF. Crossing with mice expressing FLP recombinase removed the neo. (J:98303)

Disease models

Expression

In Mice Carrying this Mutation:	70 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Spry2^tm1Mrt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spry2 Mutation: 24 strains or lines available

References

• Original: J:98303 Shim K, et al., Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Dev Cell. 2005 Apr;8(4):553-64
• All: 31 reference(s)