Meis1^tm1Mtor
Targeted Allele Detail

Summary

• Symbol: Meis1^tm1Mtor
• Name: Meis homeobox 1; targeted mutation 1, Miguel Torres
• MGI ID: MGI:3578637
• Synonyms: Meis1a^ERT2, Meis1^ER
• Gene: Meis1 Location: Chr11:18830428-18968992 bp, - strand Genetic Position: Chr11, 11.11 cM
• Alliance: Meis1^tm1Mtor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98307
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The modified estrogen receptor hormone-binding domain ERT2 was inserted in-frame with the coding region for the Meis1a isoform using the ACN cassette, which excises itself following passage through spermatogenesis. Insertion of the vector eliminated the Meis1b coding region. The mutant allele is predicted to encode an inactive protein unless tamoxifen is present. In mutants, a protein band for the expected size of Meis1a-ERT2 was present, though at a much lower level than wild-type protein. (J:98307)

Expression

In Mice Carrying this Mutation:	5 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meis1 Mutation: 46 strains or lines available

References

• Original: J:98307 Azcoitia V, et al., The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev Biol. 2005 Apr 15;280(2):307-20
• All: 8 reference(s)