Ngef^tm1Meg
Targeted Allele Detail

Summary

• Symbol: Ngef^tm1Meg
• Name: neuronal guanine nucleotide exchange factor; targeted mutation 1, Michael E Greenberg
• MGI ID: MGI:3578638
• Synonyms: ephexin1^-
• Gene: Ngef Location: Chr1:87404556-87501592 bp, - strand Genetic Position: Chr1, 44.42 cM
• Alliance: Ngef^tm1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98309
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The first two exons were deleted via cre-mediated recombionation. Western blot of mutants failed to detect protein from either N- or C- terminal domains. (J:98309)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ngef Mutation: 46 strains or lines available

References

• Original: J:98309 Sahin M, et al., Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 2005 Apr 21;46(2):191-204
• All: 2 reference(s)