Nbn^tm2Zqw
Targeted Allele Detail

Summary

• Symbol: Nbn^tm2Zqw
• Name: nibrin; targeted mutation 2, Zhao-Qi Wang
• MGI ID: MGI:3578645
• Synonyms: Nbn^F6, Nbs1^F
• Gene: Nbn Location: Chr4:15957925-15992589 bp, + strand Genetic Position: Chr4, 6.66 cM, cytoband A
• Alliance: Nbn^tm2Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98316
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites flanked exon 6. (J:98316)

Disease models

Expression

In Mice Carrying this Mutation:	187 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nbn Mutation: 59 strains or lines available

References

• Original: J:98316 Frappart PO, et al., An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med. 2005 Jun;11(6):538-44
• All: 18 reference(s)