Plxna4^tm1Hfu
Targeted Allele Detail

Summary

• Symbol: Plxna4^tm1Hfu
• Name: plexin A4; targeted mutation 1, Hajime Fujisawa
• MGI ID: MGI:3578655
• Synonyms: PlxnA4^-
• Gene: Plxna4 Location: Chr6:32121478-32565127 bp, - strand Genetic Position: Chr6, 12.9 cM, cytoband B1
• Alliance: Plxna4^tm1Hfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98330
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the exon, including the coding region for the sema domain, was deleted upon the insertion of a loxP-IRES Tak PGK-neo cassette. Western blot confirmed that mutants have the null allele. (J:98330)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plxna4 Mutation: 99 strains or lines available

References

• Original: J:98330 Suto F, et al., Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J Neurosci. 2005 Apr 6;25(14):3628-37
• All: 10 reference(s)