Celsr3^tm1Agof
Targeted Allele Detail

Summary

• Symbol: Celsr3^tm1Agof
• Name: cadherin, EGF LAG seven-pass G-type receptor 3; targeted mutation 1, Andre M Goffinet
• MGI ID: MGI:3578665
• Gene: Celsr3 Location: Chr9:108703519-108730168 bp, + strand Genetic Position: Chr9, 59.63 cM
• Alliance: Celsr3^tm1Agof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98367
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to delete exons 19-27. Transcript levels were two- to fourfold lower in mutants than in wild-type animals. RT-PCR confirmed deletion of exons 19-27. A cryptic splice acceptor site in modified intron 27 resulted in an 87-nt 5' extension of exon 28. The resulting protein lacks the GPS, 7TM and C-terminal cytoplasmic sequences. (J:98367)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Celsr3 Mutation: 122 strains or lines available

References

• Original: J:98367 Tissir F, et al., Protocadherin Celsr3 is crucial in axonal tract development. Nat Neurosci. 2005 Apr;8(4):451-7
• All: 22 reference(s)