Abcg2^tm1Bsor
Targeted Allele Detail

Summary

• Symbol: Abcg2^tm1Bsor
• Name: ATP binding cassette subfamily G member 2 (Junior blood group); targeted mutation 1, Brian P Sorrentino
• MGI ID: MGI:3578727
• Synonyms: Abcg2^-, Bcrp1^-
• Gene: Abcg2 Location: Chr6:58561476-58669436 bp, + strand
• Alliance: Abcg2^tm1Bsor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82049
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3, containing the Walker A motif, and 4 were replaced with a neo. Mutants were demonstrated to lack protein in immunoblots of kidney and liver tissue lysates. (J:82049)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcg2 Mutation: 76 strains or lines available

References

• Original: J:82049 Zhou S, et al., Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12339-44
• All: 9 reference(s)