Tnf^tm2Jods
Targeted Allele Detail

Summary

• Symbol: Tnf^tm2Jods
• Name: tumor necrosis factor; targeted mutation 2, Jonathon D Sedgwick
• MGI ID: MGI:3578747
• Synonyms: memTNF, memTNF^delta, tmTNFki
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Tnf^tm2Jods page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98591
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The nucleotides encoding 1-9 of the mature protein were deleted and an A to G transition was introduced, causing a K11E substitution. (J:98591)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 48 strains or lines available

References

• Original: J:98591 Ruuls SR, et al., Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation. Immunity. 2001 Oct;15(4):533-43
• All: 26 reference(s)