Fes^tm2Pag
Targeted Allele Detail

Summary

• Symbol: Fes^tm2Pag
• Name: feline sarcoma oncogene; targeted mutation 2, Peter A Greer
• MGI ID: MGI:3578748
• Synonyms: fps^-
• Gene: Fes Location: Chr7:80027504-80037694 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Fes^tm2Pag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98590
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 15 through 18 were replaced with a PGKneo cassette via homologous recombination. (J:98590)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fes Mutation: 41 strains or lines available

References

• Original: J:98590 Zirngibl RA, et al., Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis. Mol Cell Biol. 2002 Apr;22(8):2472-86
• All: 10 reference(s)