Jak3^tm1Tks
Targeted Allele Detail

Summary

• Symbol: Jak3^tm1Tks
• Name: Janus kinase 3; targeted mutation 1, Takashi Saito
• MGI ID: MGI:3578806
• Synonyms: Jak3^-
• Gene: Jak3 Location: Chr8:72129027-72143221 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Jak3^tm1Tks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31231
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 7.8 kb of genomic sequence including the JH regions, kinase-like domain and part of the kinase domain was replaced by the neo. RT-PCR confirmed absence of transcript in mutantbone marrow cells. (J:31231)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak3 Mutation: 84 strains or lines available

References

• Original: J:31231 Park SY, et al., Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity. 1995 Dec;3(6):771-82
• All: 6 reference(s)