Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:95898Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here. A locus on mouse Chromosome 4 between 13 cM - 26 cM showed linkage to femur medullary area (LOD=3.9), CSMI, femur ultimate stress, and tibia ultimate load (LOD=4.5). This locus is named Bntq5 (bone traits QTL 5). A second interval between 30 cM - 48 cM showed linkage to tibia ultimate load (LOD=4.5) and stiffness. This locus is named Bntq6. Previously identified bone QTLs mapping near Bntq6 are Bmch2 (35 cM), Bmd7 (57.4 cM), and Fembm5 (66 cM). |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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