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Bntq5C57BL/6J
QTL Variant Detail
Summary
QTL variant: Bntq5C57BL/6J
Name: bone traits QTL 5; C57BL/6J
MGI ID: MGI:3578909
QTL: Bntq5  Location: unknown  Genetic Position: Chr4, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

A locus on mouse Chromosome 4 between 13 cM - 26 cM showed linkage to femur medullary area (LOD=3.9), CSMI, femur ultimate stress, and tibia ultimate load (LOD=4.5). This locus is named Bntq5 (bone traits QTL 5). A second interval between 30 cM - 48 cM showed linkage to tibia ultimate load (LOD=4.5) and stiffness. This locus is named Bntq6. Previously identified bone QTLs mapping near Bntq6 are Bmch2 (35 cM), Bmd7 (57.4 cM), and Fembm5 (66 cM).

References
Original:  J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory