About   Help   FAQ
Bntq5C57BL/6J
QTL Variant Detail
Summary
QTL variant: Bntq5C57BL/6J
Name: bone traits QTL 5; C57BL/6J
MGI ID: MGI:3578909
QTL: Bntq5  Location: unknown  Genetic Position: Chr4, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

A locus on mouse Chromosome 4 between 13 cM - 26 cM showed linkage to femur medullary area (LOD=3.9), CSMI, femur ultimate stress, and tibia ultimate load (LOD=4.5). This locus is named Bntq5 (bone traits QTL 5). A second interval between 30 cM - 48 cM showed linkage to tibia ultimate load (LOD=4.5) and stiffness. This locus is named Bntq6. Previously identified bone QTLs mapping near Bntq6 are Bmch2 (35 cM), Bmd7 (57.4 cM), and Fembm5 (66 cM).

References
Original:  J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory