Bntq8^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Bntq8^DBA/2J
• Name: bone traits QTL 8; DBA/2J
• MGI ID: MGI:3578916
• QTL: Bntq8 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

An interval on mouse Chromosome 7 between 15 cM - 30 cM showed linkage to femur yield and ultimate load. This locus is named Bntq8 (bone traits QTL 8). Peak linkage occurred 15 cM with LOD=5.5. This interval also shows linkage to adiposity with peak association at 21 cM (LOD=7.6). Previously identified bone QTLs mapping near Bntq8 are Bdt4 (18 cM), Sbmd3 (11 cM), Bomd4 (8 cM), and Fcsa6 (27.8 cM).

References

• Original: J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
• All: 1 reference(s)