Irf8^myls
Spontaneous Allele Detail

Summary

• Symbol: Irf8^myls
• Name: interferon regulatory factor 8; myeloproliferative syndrome
• MGI ID: MGI:3578920
• Synonyms: Icsbp1^C294, Irf8^BXH2, IRF-8^C294, Irf8^m, Irf8^R294C
• Gene: Irf8 Location: Chr8:121463097-121483433 bp, + strand Genetic Position: Chr8, 70.05 cM
• Alliance: Irf8^myls page

Mutation origin

• Strain of Origin: BXH2/TyJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: Sequencing revealed a C-to-T transition at coding nucleotide 880, creating an arginine to cysteine substitution at codon 294 (p.R294C) within the putative IAD domain. (J:97931)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf8 Mutation: 35 strains or lines available

References

• Original: J:88564 Turcotte K, et al., Genetic control of myeloproliferation in BXH-2 mice. Blood. 2004 Mar 15;103(6):2343-50
• All: 21 reference(s)