Bntq9^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Bntq9^DBA/2J
• Name: bone traits QTL 9; DBA/2J
• MGI ID: MGI:3578961
• QTL: Bntq9 Location: unknown Genetic Position: Chr8, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

An interval on mouse Chromosome 8 between 30 cM - 60 cM showed peak linkage to tibia % mineralization at 57 cM (LOD=5.3) and peak linkage to femur yield load at 53 cM (LOD=4.1). This locus is named Bntq9 (bone traits QTL 9). Previously identified bone QTLs mapping near Bntq9 are Fembrs2 (20 cM) and Fcsa2 (40 cM).

References

• Original: J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
• All: 1 reference(s)