Bntq10^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bntq10^C57BL/6J
• Name: bone traits QTL 10; C57BL/6J
• MGI ID: MGI:3578962
• QTL: Bntq10 Location: unknown Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

An interval on mouse Chromosome 9 between 7 cM - 23 cM showedlinkage to femur modulus and stress, shear ultimate load, and tibia cortical area. This locus is named Bntq10 (bone traits QTL 10). Maximum linkage occurs at 7 cM for tibia cortical area (LOD=3.5). A potential candidate gene for Bntq10 is Acp5 at 6 cM. Asecond interval between 36 cM - 65 cM showed linkage to tibia stiffness and tibia ultimate load (LOD=3.6). This locus is named Bntq11. Maximum linkage occurs at 65 cM for tibia ultimate load (LOD=3.6). Previously identified bone QTLs mapping near Bntq11 are Bmd10 (48 cM), Tbbmd4 (49 cM), and Vtbt8 (48 cM).

References

• Original: J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
• All: 1 reference(s)