Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:95898Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here. An interval on mouse Chromosome 11 between 31 cM - 74 cM showed linkage to tibia ultimate strain, tibia length, body length, and adiposity. This locus is named Bntq12 (bone traits QTL 12). Peak linkage to body length occurred at 34 cM (LOD=4.7) and peak linkage to adiposity occurred at 46 cM cM (LOD=5). Previously identified bone QTLs mapping near Bntq12 are Bmd11 (31 cM), Sbmd4 (49 cM), and Tbbmd5 (43.7 cM). |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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