Bntq13^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Bntq13^DBA/2J
• Name: bone traits QTL 13; DBA/2J
• MGI ID: MGI:3578969
• QTL: Bntq13 Location: unknown Genetic Position: Chr12, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

An interval on mouse Chromosome 12 from 47 cM - 57 cM showed linkage to femur head diameter. This locus in named Bntq13 (bone traits QTL 13) and is also associated with several other bone phenotypes, such as tibia CSMI, tibia cortical area, and tibia medullary area. Peak linkage occurred at 53 cM with LOD= 5.6. A previously identified bone QTL mapping near Bntq13 is Vtbt14 at 53 cM. A potential candidate gene for Bntq13 is Fos at 40 cM.

References

• Original: J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
• All: 1 reference(s)