Bntq14^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Bntq14^DBA/2J
• Name: bone traits QTL 14; DBA/2J
• MGI ID: MGI:3578971
• QTL: Bntq14 Location: unknown Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

An interval on mouse Chromosome 13 between 16 cM - 36 cM showed linkage to body mass index, body weight, femur stiffness, tibia length, and adiposity. This locus is named Bntq14 (bone traits QTL 14). Maximal linkage occurred at 24 cM for body weight (LOD=6.6) and at 26 cM for tibia length (LOD=4.4). Previously identified bone QTLs mapping near Bntq14 are Bmch6 (38 cM), Bmd13 (35 cM), and Vtbt15 (30 cM).

References

• Original: J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
• All: 1 reference(s)