Tg(Mt1-Hgf)#Lmb
Transgene Detail

Summary

• Symbol: Tg(Mt1-Hgf)#Lmb
• Name: transgene insertion, Glenn Merlino
• MGI ID: MGI:3579068
• Synonyms: MT-HGF/SF, SF/HGF, Tg(Mt1-HGFSF)#Lmb, Tg(Mt-HGFSF)#Lmb
• Transgene: Tg(Mt1-Hgf)#Lmb Location: unknown
• Alliance: Tg(Mt1-Hgf)#Lmb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-Hgf)#Lmb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hgf (MGI:96079)

• Tg(Mt1-Hgf)#Lmb expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mt1 (MGI:97171)

• Mutation details: The transgene consists of a mouse metallothionein 1 promoter, the entire mouse hepatocyte growth factor cDNA sequence, a human growth hormone polyadenylation site, and mouse Mt1 5' and 3' flanking regions. (J:34022)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mt1-Hgf)#Lmb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Multiple transgenic lines were produced: 18, 19, 22, 27, 31, and 37.

References

• Original: J:34022 Takayama H, et al., Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5866-71
• All: 11 reference(s)