Ptprc^tm1Tyb
Targeted Allele Detail

Summary

• Symbol: Ptprc^tm1Tyb
• Name: protein tyrosine phosphatase receptor type C; targeted mutation 1, Victor L J Tybulewicz
• MGI ID: MGI:3579087
• Synonyms: Cd45^-
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^tm1Tyb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57681
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 12, which encodes part of the extracellular domain and is common to all isoforms, was disrupted by the insertion of a neomycin resistance gene. Flow cytometry of splenocytes, lymphocytes, lymph node and bone marrow cells with an antibody recognizing all isoforms failed to detect protein on any cells. (J:57681)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 189 strains or lines available

References

• Original: J:57681 Mee PJ, et al., Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice. Eur J Immunol. 1999 Sep;29(9):2923-33
• All: 7 reference(s)