Nr2f2^tm2.1Tsa
Targeted Allele Detail

Summary

• Symbol: Nr2f2^tm2.1Tsa
• Name: nuclear receptor subfamily 2, group F, member 2; targeted mutation 2.1, Sophia Y Tsai
• MGI ID: MGI:3579117
• Synonyms: COUP-TFII^flox
• Gene: Nr2f2 Location: Chr7:70001692-70016483 bp, - strand Genetic Position: Chr7, 38.66 cM
• Alliance: Nr2f2^tm2.1Tsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98520
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: Exons 1-3 remained flanked by loxP sites as cre expression resulted in the excision of a neo at the 3' end of the locus. A lacZ remained downstream of the floxed exons. (J:98520)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa	involves: 129S7/SvEvBrd
cn2	Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa	involves: 129S7/SvEvBrd * C57BL/6
cn3	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa Prox1^tm3(cre/ERT2)Gco/Prox1^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
cn4	Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa Pgr^tm2(cre)Lyd/Pgr^+	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
cn5	Gt(ROSA)26Sor^tm1(CAG-NR2F1)Mjts/Gt(ROSA)26Sor^+ Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa Pgr^tm2(cre)Lyd/Pgr^+	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
cn6	Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL
cn7	Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa Rbpj^tm1Hon/Rbpj^tm1Hon Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL
cn8	Nr2f1^tm2.1Mjts/Nr2f1^tm2.1Mjts Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa Tg(rx3-icre)1Mjam/0	involves: 129S7/SvEvBrd
cn9	Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa Tg(rx3-icre)1Mjam/0	involves: 129S7/SvEvBrd
cn10	Nr2f1^tm2.1Mjts/Nr2f1^tm2.1Mjts Nr2f2^tm2.1Tsa/Nr2f2^+ Tg(rx3-icre)1Mjam/0	involves: 129S7/SvEvBrd
cn11	Nr2f1^tm2.1Mjts/Nr2f1^+ Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa Tg(rx3-icre)1Mjam/0	involves: 129S7/SvEvBrd
cn12	Amhr2^tm3(cre)Bhr/Amhr2^+ Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa	involves: 129S7/SvEvBrd
cn13  Disease Model	Nkx3-2^tm1(cre)Tsa/Nkx3-2^+ Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa	involves: 129S7/SvEvBrd * C57BL/6

Phenotypes:

Affected Systems	hm1	cn2	cn3	cn4	cn5	cn6	cn7	cn8	cn9	cn10	cn11	cn12		cn13
show or hide all annotated terms Sex:
cardiovascular system		√										√	√
abnormal blood vessel morphology		√
abnormal placental labyrinth vasculature morphology												√	√
abnormal vein morphology		√
hemorrhage		√										√	√
vaginal hemorrhage												√
digestive/alimentary system														√
abnormal digestive system development														√
abnormal stomach morphology														√
small forestomach														√
abnormal forestomach-glandular stomach junction morphology														√
abnormal stomach pyloric region morphology														√
abnormal gastric parietal cell morphology														√
abnormal stomach epithelium morphology														√
abnormal stomach glandular epithelium morphology														√
abnormal stomach smooth muscle circular layer morphology														√
small stomach														√
embryo												√	√
abnormal placental labyrinth vasculature morphology												√	√
increased trophoblast giant cell number												√	√
abnormal maternal decidual layer morphology												√
decreased spongiotrophoblast cell number												√	√
absent placental labyrinth												√	√
abnormal placenta development												√	√
endocrine/exocrine glands														√
abnormal gastric parietal cell morphology														√
homeostasis/metabolism			√									√	√
edema			√									√	√
immune system			√			√	√
abnormal lymphatic vessel morphology			√
decreased lymphatic vessel endothelial cell number						√	√
mortality/aging		√					√					√	√
embryonic lethality, complete penetrance		√
embryonic lethality, incomplete penetrance							√					√	√
muscle														√
abnormal stomach smooth muscle circular layer morphology														√
nervous system								√						√
abnormal enteric neuron morphology														√
absent optic disk								√
pigmentation								√
abnormal retina pigment epithelium morphology								√
reproductive system	√			√	N							√
reproductive system phenotype					N
vaginal hemorrhage												√
abnormal maternal decidual layer morphology												√
abnormal myometrium morphology												√
short uterine horn												√
impaired embryo implantation												√
increased miscarriage rate												√
abnormal uterine environment												√
female infertility				√
reduced female fertility	√											√
vision/eye								√	N	√	√
vision/eye phenotype									N
absent optic disk								√
abnormal retina pigment epithelium morphology								√
abnormal eye development								√
abnormal optic fissure closure										√	√
abnormal optic stalk morphology								√
coloboma								√		√	√
microphthalmia								√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn13
congenital diaphragmatic hernia IDs congenital diaphragmatic hernia       DOID:3827 ICD10CM:K44 MESH:D006548 NCI:C34687 OMIM:142340 OMIM:222400 OMIM:610187 ORDO:2140 UMLS_CUI:C0019284 Close	√

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2f2 Mutation: 28 strains or lines available

References

• Original: J:98520 Takamoto N, et al., COUP-TFII is essential for radial and anteroposterior patterning of the stomach. Development. 2005 May;132(9):2179-89
• All: 43 reference(s)